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The FDA will meet in July to discuss its position on seven peptides, including molecules it deemed unsafe in a Biden-era ruling
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GLP-1R agonists have been approved for the treatment of T2DM since 2005, but it was only with the approval of tirzepatide (a dual GLP-1R/GIPR agonist) in 2022 that a drug acting on GIPR was used clinically (Le Roux et al., 2023)
An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]
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